NFL Picks - Week 5
| Home | Line | Away |
|---|---|---|
| Broncos | -3.5 | Colts |
| Packers | -8.5 | Giants |
| Bills | -14 | Steelers |
| Buccaneers | -9 | Falcons |
| Jets | +3 | Dolphins |
| Vikings | -7 | Bears |
| Jaguars | -7 | Texans |
| Patriots | -3 | Lions |
| Browns | +3 | Chargers |
| Commanders | +2.5 | Titans |
| Saints | -5.5 | Seahawks |
| Panthers | +6.5 | 49ers |
| Cardinals | +5.5 | Eagles |
| Rams | -4.5 | Cowboys |
| Ravens | -3 | Bengals |
| Chiefs | -7 | Raiders |